Spravato® Treatment Center in Columbus, Ohio

When nothing else has worked, there’s still hope.

We offer SPRAVATO® (esketamine) nasal spray treatment as part of our commitment to providing innovative, compassionate care for treatment-resistant depression.

This FDA-approved treatment works in new ways to open pathways in the brain, giving hope to those who haven’t responded to traditional antidepressants. If you’ve tried multiple therapies without success, SPRAVATO® may be the next step on your path to wellness.

Have questions? Schedule a welcome call first.

Refer a Patient: Fax form to 866-309-4381.

Learn More

  • Treatment-resistant depression (TRD) affects about 30% of those diagnosed with major depressive disorder. It’s a condition where traditional treatments—such as multiple antidepressants and adjunctive therapies, including second generation antipsychotic medications—may not bring relief.

    If other treatments have not worked, therapies like SPRAVATO®, Transcranial Magnetic Stimulation (TMS), ketamine, or electroconvulsive therapy (ECT) may offer the breakthrough you’re seeking.

    At Origin Mental Wellness, we understand how frustrating it can be to search for answers without results. That’s why we offer SPRAVATO® as a promising treatment option for those struggling with TRD.

  • SPRAVATO® (esketamine) is an FDA-approved nasal spray that offers new hope to adults with treatment-resistant depression.

    It’s used alongside an oral antidepressant to support individuals who haven’t found relief through traditional treatments.

    SPRAVATO® is indicated for treatment resistant depression (TRD) in adults adults with major depressive disorder, and major depressive disorder with acute suicidal thoughts

    SPRAVATO® can only be administered under the supervision of a certified healthcare professional at a certified treatment center under the Risk Evaluation and Mitigation Strategy Program (REMS).

    If you’ve tried two or more antidepressants without success, we welcome you to call us to explore whether SPRAVATO® may be right for you.

    Click here to learn more about SPRAVATO®.

  • SPRAVATO® treatment at Origin Mental Wellness follows a structured plan designed for safety and effectiveness: 

    Weeks 1-4: Treatments are administered twice a week.
    Weeks 5-8: Sessions reduce to one per week.
    Week 9 and after: Treatments occur every two weeks or as needed, depending on your response.

    Each session lasts about two hours, during which a healthcare provider closely monitors your experience.

What to Expect

The Process

Our process begins with an intake assessment to ensure SPRAVATO® is the best option for you. After the assessment, we schedule an orientation to discuss the treatment in more detail and answer any questions. You’ll then have the freedom to self-schedule your appointments, following the structured schedule to optimize your results. Each session lasts approximately two hours, during which a healthcare provider closely monitors your progress.

Administering SPRAVATO®

During each session, you’ll administer the SPRAVATO® nasal spray yourself, guided by a healthcare provider who oversees dosage and timing. Arrive on time and remain consistent with your scheduled appointments for the best outcomes. Throughout your treatment, our team monitors your vitals to ensure your safety and to observe your response to the medication. You will need to arrange transportation to and from the clinic, as you won’t be able to drive after each session due to potential side effects.

Side Effects

If SPRAVATO® side effects occur, they usually happen right after taking SPRAVATO® and go away the same day.

    • Feeling very happy and excited

    • Lack of energy 

    • Feeling sleepy (sedation) 

    • Feeling disconnected from yourself and surroundings (Dissociation) 

    • Feeling anxious 

    • Dizziness

    • Nausea

    • Increasing blood pressure 

    • Feeling drunk 

    • Feeling Sleepy (sedation) 

    • Breathing slower than usual (Respiratory depression) 

    • Feeling disconnected from yourself and surroundings (Dissociation) 

    • Abuse and misuse 

    • Increased blood pressure 

    • Inability to think clearly (Cognitive impairment)

    • Increased suicidal thoughts 

    • Aneurysmal vascular disease 

    • History of intracerebral hemorrhage 

    • Hypersensitivity to esketamine and or ketamine. 

Commitment to Treatment

SPRAVATO® requires a long-term commitment to see results.

We understand that committing to a consistent treatment schedule can be challenging, but our team supports you in maintaining your routine to maximize benefits. Although SPRAVATO® doesn't help everyone, studies show that by the fourth week of treatment, more than half of those using SPRAVATO® alongside an oral antidepressant experience significant symptom relief. At Origin Mental Wellness, we’re here to guide you through every step, dedicated to helping you find a lasting path to wellness.

Are You Ready to Take the Next Step?

If you or someone you know is dealing with treatment-resistant depression, reach out to us to learn more about SPRAVATO® and how it can help. Together, we’ll explore a treatment plan that’s right for you.

Refer a Patient: Fax form to 866-309-4381.